General Evaluation of Covid-19 Diagnosis Methods

 After the first case has appeared in China, the disease, COVID-19, continues to spread an omnipresent threat to global health. The reliable, fast, and effective diagnosis methods are important to control the pandemic. Today, the real-time Reverse Transcriptase (RT-PCR) test is the main diagnostic practice as a gold standard method for accurate diagnosis of this disease. On the other side, serological assays are easy to be implemented for disease screening. However, the actual limitations of these methods are required skilled personnel and specialized infrastructure. Thus, in this direction, there is an urgency to be implanted an appropriate method for the diagnosis of COVID-19 disease. Nowadays, the Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) technique is preferred because of the portable, easily implanted, and effective for diagnosis. In this assay, three main diagnosis methods (RTPCR, serological tests, and RT-LAMP) are evaluated s within the scope of the COVID-19 diagnosis.

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A Theoretical Proposal of Epidemic Monkeypox Genius, Based on The Experience of Von Boenninghausen

 I am writing this short letter to propose the homeopathic epidemic genius for the infectious disease that has recently appeared in Europe, called monkeypox. While always remembering that it is always advisable to treat any disease individually, seeking the best unitary remedy for the case, as masterfully expressed by Prof. Hahnemann (§ 153,154,155,273) [1], it should also not be forgotten that the most important epidemics of the past have always been treated with a handful of remedies at most, and very often one remedy was the most suitable, and was called epidemic genius (§ 99-103, paragraphs never changed in the various editions). The intent of this letter, is therefore to propose in a strictly theoretical way as the epidemic had just appeared, following both Hahnemann’s dictates, and the logic of Homeopathy proposed by Stuart Close: exact observation, correct interpretation, rational explanation, and scientific construction [7], the epidemic genius of monkeypox, based on the observations and experience of one of the greatest Homeopaths in history, Hahnemann’s favorite pupil, Baron Von Boenninghausen.

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Microbiological Isolates in Patients with Community-Acquired PNEUMONIA, COMPARATIVE STUDY of Three Methods

 Community-acquired pneumonia constitutes a major health problem worldwide. Objective: to determine the bacterial spectrum in patients hospitalized for pneumonia in a local context. Method: The results of 208 blood cultures, 69 sputum cultures, and 8 samples of respiratory secretions and lung tissue obtained postmortem were analyzed. The positivity index was determined for each method used, as well as the frequency of the isolated germs. The positivity rate for respiratory secretions (postmortem) was 87.5%, lung tissue 75%, sputum 37.6%, and blood culture 10.6%. The isolates of Klebsiella pneumoniae (20) and Streptococcus pneumoniae (19) represented 64% of the total isolates.

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An Emergence of Multidrug Resistant Nosocomial Pathogen- Acinetobacter Baumannii

 Nosocomial infections have been recognized as one of the most critical problems in hospitalization, particularly in critical care units. As these infections prolong hospitalization, require extensive diagnostics and treatment, leads to high cost. The emergence of multidrug resistant pathogens has become a threat in critically ill, immuno-compromised patients due to the extensive use of antimicrobial. The most common types of nosocomial infections are pneumonia, urinary tract infections, meningitis, wound, soft tissue, surgical site infections and blood stream infections. These infections can be life threatening, capable of making of therapeutic options very difficult and limits the critical care settings. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp are most common nosocomial pathogens. Among all nosocomial species Multidrug Resistance (MDR) A. baumnaii is most pathogenic microorganism. Here a review on A. baumannii in relation to nosocomial infection is carried out. This review includes risk factors, diagnosis modalities, pathogenesis, MDR properties, mechanism of MDR and treatment of A. baumannii.

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