Characterization of Mycobacterium Tuberculosis Complex Strains: A Multicenter Retrospective Greek Study_Crimson Publishers

Characterization of Mycobacterium Tuberculosis Complex Strains: A Multicenter Retrospective Greek Study by Lamprini Gkaravela in Cohesive Journal of Microbiology & Infectious Disease

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000539.php

The aim was to compare clinical characteristics, antimicrobial resistance and 24-loci variable numbers of tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTR) patterns among M. tuberculosis complex isolates (MTBC) recovered from patients living in Greece during a two-year period (2009-10). Isolates from 117 tuberculosis patients identified as MTBC by a molecular method were phenotypically tested for their antimicrobial susceptibility. Clonality was accessed by MIRU-VNTR. Among 117 patients with confirmed microbiologic tuberculosis, 90 (76.9%) were of Greek origin, and 27 (23.1%) foreigners. Only 67 out of the 117 (57.3%) patients were officially reported to the Hellenic Center for Disease Control and Prevention. Phenotypic susceptibility testing revealed 10 isolates resistant to isoniazid (8.5%), two to rifampicin (1.7%), five to ethambutol (4.3%) and 17 to streptomycin (14.5%). In total two multidrug-resistant strains (1.7%) were detected. MIRU-VNTR classified 35 strains (29.9%) into 10 Families, whereas, 82 (70.1%) were not classified into any known Family. MTBC strains belonging to known Families were more commonly isolated from people living in cities and foreigners and showed a trend to higher resistance percentages to isoniazid and rifampicin. Most isolates from Greek rural areas do not belong to any known Family and are characterized by lower resistance rates.

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Characterization of Mycobacterium Tuberculosis Complex Strains: A Multicenter Retrospective Greek Study_Crimson Publishers

Characterization of Mycobacterium Tuberculosis Complex Strains: A Multicenter Retrospective Greek Study by Lamprini Gkaravela in Crimson Publishers

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000539.php

The aim was to compare clinical characteristics, antimicrobial resistance and 24-loci variable numbers of tandem repeats of mycobacterial interspersed repetitive units (MIRU-VNTR) patterns among M. tuberculosis complex isolates (MTBC) recovered from patients living in Greece during a two-year period (2009-10). Isolates from 117 tuberculosis patients identified as MTBC by a molecular method were phenotypically tested for their antimicrobial susceptibility. Clonality was accessed by MIRU-VNTR. Among 117 patients with confirmed microbiologic tuberculosis, 90 (76.9%) were of Greek origin, and 27 (23.1%) foreigners. Only 67 out of the 117 (57.3%) patients were officially reported to the Hellenic Center for Disease Control and Prevention. Phenotypic susceptibility testing revealed 10 isolates resistant to isoniazid (8.5%), two to rifampicin (1.7%), five to ethambutol (4.3%) and 17 to streptomycin (14.5%). In total two multidrug-resistant strains (1.7%) were detected. MIRU-VNTR classified 35 strains (29.9%) into 10 Families, whereas, 82 (70.1%) were not classified into any known Family. MTBC strains belonging to known Families were more commonly isolated from people living in cities and foreigners and showed a trend to higher resistance percentages to isoniazid and rifampicin. Most isolates from Greek rural areas do not belong to any known Family and are characterized by lower resistance rates.

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Why are there Doubts about Vaccines Efficacy yet in 2018?_Crimsonpublishers

 Why are there Doubts about Vaccines Efficacy yet in 2018? by João Paulo Martins do Carmo in Crimson publishers

https://crimsonpublishers.com/cjmi/pdf/CJMI.000538.pdf

Despite many articles that have been already published in this Cohesive Journal of Microbiology and Infectious Disease, it is important to stress that some of them are not necessarily in agreement with the view of this editor. Especially the ones called “opinion”, in which their authors expresses what they think. But even when a scientist thinks in writing, it is good tone to show some references, because if they can’t reference their opinion, there might be some references in return showing disagreement or contradictions to their simplistic view. If you don’t believe in vaccines, for example, you should reference which vaccine does not work and why, scientifically, so that the discussion should be open to anyone who would like to debate it. Generalizations are not scientific, not safe and do not contribute to the scientific advancement of knowledge.

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