Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) -Crimson Publishers

Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) by Carlo PJM Brouwer in Cohesive Journal of Microbiology & Infectious Disease

Antimicrobial peptides are omnipresent in nature and act as the first line of defence of the host against infectious agents. A synthetic antimicrobial peptide derived from the N-terminus of human lactoferrin hLF(1-11) (GRRRRSVQWCA), displays antibacterial as well as antifungal activity in vitro andin vivo. In order to elucidate the mechanism of antimicrobial action of hLF(1-11), we have synthesised several peptides analogues derived from hLF(1- 11) to test their activity against various fungal and bacterial strains. In this way, a general trend on the importance of the order and position of amino acid residues for biological activity against various organisms could be drawn.

 https://crimsonpublishers.com/cjmi/fulltext/CJMI.000512.php

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Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS-Crimson Publishers

Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS by João Paulo Martins do Carmo in Cohesive Journal of Microbiology & Infectious Disease

The ability of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate human monocytes/macrophages for virulent Paracoccidioides brasiliensis killing was evaluated. Peripheral blood monocytes (MO) and monocyte-derived macrophages (M∅) were activated with different concentrations of GM-CSF. Afterwards, cells were challenged with P. brasiliensis strain 18 (Pb18) and the fungicidal activity was evaluated, plating and counting the Colony Forming Units (CFU) after 10 days. GM-CSF activated MO and M∅ for P. brasiliensis killling in a concentration-dependent manner. There was an association between this fungicidal activity and the high levels of H₂O₂ release by the activated cells

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000511.php

 

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The Most Informative Mistake about Report Interpretation of Slit Skin Smear-Crimson Publishers

The Most Informative Mistake about ReportInterpretation of Slit Skin Smear by Pugazhenthan Thangaraju in Cohesive Journal of Microbiology & Infectious Disease

As a beginner in leprosy field, we do encounter with mistake of interpretation of results of slit skin Smear(SSS). A skin smear is a diagnostic & prognostic test in which a sample of material is Collected from a tiny cut in the skin and then stained for M. lepra. This test is done for to confirm clinical diagnosis of multi-bacillary leprosy in a suspect, to determine the state of infectivity, to help in diagnosis of relapse of leprosy, for classification and prognosis and to get negative certificate. The lepra bacilli will be seen as pink rods. The bacilli may be seen as in single, or in small groups or as a closely packed bundle called globi or in any combinations of these.

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000510.php

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Time Times Time=Time (D2•Y=Z)-Crimson Publishers

Time Times Time=Time (D²•Y=Z) by Andres J Washington*in Cohesive Journal of Microbiology & Infectious Disease

To determine the number of days which exist in 210,240 hours divide 210,240 by 24; 210,240÷24 = 8,760 days. (Note here that 8,760 represents days and not hours as before.) To determine the number of years which exist in 8,760 days divide 8,760 by 365; 8,760÷365 = 24 years. In conclusion, the number of hours in a day, 24 multiplied by the number of hours in a year, 8,760 equals 210,240 hours which is equivalent to 24 years of time. The interesting aspect about this is that the number 24 is coincidental to hours and years 

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000509.php


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Vegetable Microbiology: Concern for Human Health-Crimson Publishers

Vegetable Microbiology: Concern for Human Health by Bhallan Singh Sekhon*, Yudhvir Singh, Surbhi Sharma, Simran Sharma and Vishalakshi in Cohesive Journal of Microbiology & Infectious Disease.

In the health conscious society of 21st century, vegetables form an integral part of human diet. They provide us essential vitamins and minerals, dietary fiber, phytochemicals, and also help in reducing the risk of dangerous diseases. World Health Organization (WHO), European Food Safety Authority (EFSA), Food & Agricultural Organization (FAO) and French Agency for Food Safety (AFSSA) recommended the intake of atleast five servings of vegetables and fruits per day. In general, freshly consumed vegetables are considered to be more vital than the cooked ones. However, they are usually accompanied with many food borne diseases, thus poses safety threats.

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000508.php

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Yellow Fever Vaccine in Brazil: A Revolt Backwards 100 Years Later?-Crimson Publishers

Yellow Fever Vaccine in Brazil: A Revolt Backwards 100 Years Later? by João Paulo Martins do Carmo in Cohesive Journal of Microbiology & Infectious Disease

Who arrives in Rio de Janeiro from the Galeao Airport heading to the famous Ipanema and Copacabana beaches (who haven't heard of the girl, from Tom Jobim's song, and the place immortalized in Barry Manilow's voice?) is able to see the Castelo Mourisco (which would be, in a free translation, something like "the Mourish Castle"), head of our Foundation Oswaldo Cruz - FIOCRUZ. In March 2017, the year Oswaldo Cruz-100 years of his legacy in Brazil was instituted to showcase his role in science and health in a national project. He was head of the group wishing to shape the small serotherapeutic lab, focused in vaccines and sera production, into a great experimental medicine one, like the Paris' Institute Pasteur, where he had studied Microbiology, Serotherapy and Immunology, and Legal Medicine at the Toxicology Institute. 

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000507.php


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Crimson Publishers-Malaria Disease Diagnosis-Current Status of CAD Based Approach

Malaria Disease Diagnosis-Current Status of CAD Based Approach by Sanjay Nag and Samir Kumar Bandyopadhyay*in Cohesive Journal of Microbiology & Infectious Disease

The CAD based approach with digital microscopy and advance image processing techniques coupled with intelligent system is the best cost effective diagnostic solution. Such software is being developed to assist pathologists and haematologist. This paper review different CAD methods.

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000506.php