Wednesday, August 28, 2019

Friday, August 23, 2019

Viable Monitoring During the Filling of a Terminally Sterilized Pharmaceutical Product-Risk Based Approach-Crimson Publishers

Viable Monitoring During the Filling of a Terminally Sterilized Pharmaceutical Product-Risk Based Approach by Ahmed Assem in Infectious Disease Open Access Journals_Crimson Publishers

This article addresses a risk based approach to establish a routine monitoring program of viable (I.e. microorganisms) in a controlled environment used to produce pharmaceutical products that are intended to be terminally sterilized. Current applicable quality system regulation & GMP require appropriate environment to be established, maintained and monitored for the manufacturing of the terminally sterilized pharmaceutical meanwhile the appropriate environmental monitoring plan is not clearly specified & a risk based approach will be a valuable tool to design a suitable program

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000527.php


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Friday, June 21, 2019

Huge Genetic Inclusion during Conversion of R-Plasmids into MDR Conjugative Plasmids in Multidrug-Resistant Bacteria: Crimson Publishers

Huge Genetic Inclusion during Conversion of R-Plasmids into MDR Conjugative Plasmids in Multidrug-Resistant Bacteria by Asit Kumar Chakraborty in Cohesive Journal of Microbiology & Infectious Disease: Crimson Publishers_Open Access High Impact Articles



High rate infections and deaths due to multidrug-resistant pathogens have created a horror worldwide. Because MDR bacteria are present in river, sea and air as well as in all household matters, such infections are ubiquitous. Most dangerous step occurred when R-plasmids and integrons (2-9kb) were combined with F’-conjugative plasmid (50-500kb) creating MDR conjugative plasmids that highly donated the mdr genes into household pathogens in the environment. Now 40% of household Escherichia coli and Staphylococcus aureus like Gram (+) and Gram (-) bacteria are ampicillin resistant and also to some extent tetracycline, chloramphenicol, streptomycin, erythromycin, ciprofloxacin, sulfamethoxazole and neomycin resistant.



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Friday, June 7, 2019

Prevalence of Coccidiosis in Back Yard Chicken in and Around DebereTabere Town, South Gondar Zone, Amhara Regional State, Ethiopia: Crimson Publishers

Prevalence of Coccidiosis in Back Yard Chicken in and Around DebereTabere Town, South Gondar Zone, Amhara Regional State, Ethiopia by Temesigen W Molla in Cohesive Journal of Microbiology & Infectious Disease: Crimson Publishers_World journal of microbiology and biotechnology

A cross sectional study was carried out to estimate the prevalence of chicken coccidial infections and assessment of the associated risk factor in backyard chickens in and around Debre Tabore town, South Gondar Zone, Northwest Ethiopia from October 2015 and May 2016.Floatation techniques were used for qualitative study of coccidialoocyst. Descriptive statistics was used to express prevalence while chi-square test used to assess if there was statistically significant association between targeted host factors and coccidial infection. The degrees of these associations were quantified using crude and adjusted odds ratio. Statistical significance was assumed if the confidence interval (CI) did not include one among its values or whenever p-value was less than 5%. The overall animal prevalence for coccidial infections was 21.4% (48/224) and the prevalence was significantly associated with breed (p=0.019), age (p=0.028) and sex (p=0.004) of the study animals. In a multivariable logistic regression analysis, female (Adjusted Odds Ratio (AOR)=0.3; 95%CI:0.17-0.68) and exotic breeds (AOR=0.46; 95%CI:0.23-0.93) were found less likely infected with coccidialoocystes as compared to male and local chickens. However, increased risk for coccidial infection was recorded in adult chicken (AOR=2.04; 95%CI:1.02-4.08) as compared to the grower chickens. In conclusion, this study showed coccidial infection could be important in the backyard chickens in the study area even though the overall prevalence was relatively low. Moreover, the prevalence was higher in adults than the growers, which alerts the need to undertake suitable and practically applicable control and prevention measures in the parent stocks.
 
 
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Saturday, May 25, 2019

AN EVALUATION ON ORAL VESTIBULAR SCHWANNOMA GROWTH FROM THE VIEWPOINT OF MOLECULAR BIOLOGY_ CRIMSON PUBLISHERS


An Evaluation on Oral Vestibular Schwannoma Growth from the Viewpoint of Molecular Biology by Bing H Tang* in Cohesive Journal of Microbiology & Infectious Disease: Crimson Publishers_ Infectious disease Journals


This author has known Medical Hypotheses several years ago, unfortunately did not know that it is available online lately, until recently when he read Prof. Gong Peng’s important hypotheses. Has been honored to receive the invitation from Prof. Ping Gong [an oral surgeon] for our potential collaboration. In the meantime, please correct some possible errors in this author’ writing as presented below, and the possibility of applying his own concepts into the important future research.

This author read with great interest the article written by Baser. Predictors of vestibular schwannoma growth in patients with neurofibromatosis. Their research expresses result of two longitudinal studies of growth rates of vestibular schwannomas (VSs) in patients with neurofibromatosis Type 2 (NF2) differs from each other as to whether VS growth rates decrease or increase when ever patients getting older. The authors undertook their study to assess the relationship between VS growth rates and patient age and type of constitutional NF2mutation; they also examined the in VS growth rates among multiple patients in families with NF2. Methods by using Gadolinium-enhanced magnetic resonance images obtained in 18 patients with inherited NF2 from 11 unrelated families whom were retrospectively analyzed. The patients had been observed for a period with a median of 4 years. Volumes of the VSs were checked using a two component box model (intrameatal and extrameatal parts checked respectively)


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please click on link: https://crimsonpublishers.com/

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 please click on link: https://crimsonpublishers.com/cjmi/