Implementation of Quality Risk Management for Manufacturing of a Non-Sterile Pharmaceutical Product- Case study-Crimson Publishers

Implementation of Quality Risk Management for Manufacturing of a Non-Sterile Pharmaceutical Product- Case study by Ahmed Assem in  Cohesive Journal of Microbiology & Infectious Disease

This article will address a model for implementation of quality risk management for the manufacturing of a non-sterile product through a real case. The risk addressed in the article is the microbiological contamination and the procedure followed was Failure Mode Effect Analysis (FMEA) mainly. It can be used by pharmaceutical scientist to evaluate the possible causes of microbiological contamination of their products and will show how to evaluate the risks and describe a monitoring plan based on the associated risks

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000514.php

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The Emergence and Re-emergence of Infectious Diseases: A Challenge for Humanity and Health Systems in the 21st Century-Crimson Publishers

The Emergence and Re-emergence of Infectious Diseases: A Challenge for Humanity and Health Systems in the 21^st Century by Reyes-Esparza Jorge in Cohesive Journal of Microbiology & Infectious Disease

When one reads about the challenges facing humanity this century, it becomes clear we must do more with less. A growing population must be provided with welfare while using fewer resources, particularly water, land (working surface) and energy. An aging population, chronic degenerative diseases, addictions, healthcare costs and the integration of health systems all entail challenges in the health department. However, we must not forget the presence of old and new infections that “threaten” to become pandemics. Here I will address the subject of global epidemiology and, in particular, the risk of what can be termed “global” pandemics, as was the case, a century ago, of Spanish influenza. By conservative estimates, this killed 50 million people (some sources estimate double the number of deaths).

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000513.php

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Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) -Crimson Publishers

Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) by Carlo PJM Brouwer in Cohesive Journal of Microbiology & Infectious Disease

Antimicrobial peptides are omnipresent in nature and act as the first line of defence of the host against infectious agents. A synthetic antimicrobial peptide derived from the N-terminus of human lactoferrin hLF(1-11) (GRRRRSVQWCA), displays antibacterial as well as antifungal activity in vitro andin vivo. In order to elucidate the mechanism of antimicrobial action of hLF(1-11), we have synthesised several peptides analogues derived from hLF(1- 11) to test their activity against various fungal and bacterial strains. In this way, a general trend on the importance of the order and position of amino acid residues for biological activity against various organisms could be drawn.

 https://crimsonpublishers.com/cjmi/fulltext/CJMI.000512.php

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Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS-Crimson Publishers

Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS by João Paulo Martins do Carmo in Cohesive Journal of Microbiology & Infectious Disease

The ability of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate human monocytes/macrophages for virulent Paracoccidioides brasiliensis killing was evaluated. Peripheral blood monocytes (MO) and monocyte-derived macrophages (M∅) were activated with different concentrations of GM-CSF. Afterwards, cells were challenged with P. brasiliensis strain 18 (Pb18) and the fungicidal activity was evaluated, plating and counting the Colony Forming Units (CFU) after 10 days. GM-CSF activated MO and M∅ for P. brasiliensis killling in a concentration-dependent manner. There was an association between this fungicidal activity and the high levels of H₂O₂ release by the activated cells

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The Most Informative Mistake about Report Interpretation of Slit Skin Smear-Crimson Publishers

The Most Informative Mistake about ReportInterpretation of Slit Skin Smear by Pugazhenthan Thangaraju in Cohesive Journal of Microbiology & Infectious Disease

As a beginner in leprosy field, we do encounter with mistake of interpretation of results of slit skin Smear(SSS). A skin smear is a diagnostic & prognostic test in which a sample of material is Collected from a tiny cut in the skin and then stained for M. lepra. This test is done for to confirm clinical diagnosis of multi-bacillary leprosy in a suspect, to determine the state of infectivity, to help in diagnosis of relapse of leprosy, for classification and prognosis and to get negative certificate. The lepra bacilli will be seen as pink rods. The bacilli may be seen as in single, or in small groups or as a closely packed bundle called globi or in any combinations of these.

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000510.php

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