Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) -Crimson Publishers

Structure-Activity Relationship Study of Synthetic Variants Derived from the Highly Potent Human Antimicrobial Peptide hLF(1-11) by Carlo PJM Brouwer in Cohesive Journal of Microbiology & Infectious Disease

Antimicrobial peptides are omnipresent in nature and act as the first line of defence of the host against infectious agents. A synthetic antimicrobial peptide derived from the N-terminus of human lactoferrin hLF(1-11) (GRRRRSVQWCA), displays antibacterial as well as antifungal activity in vitro andin vivo. In order to elucidate the mechanism of antimicrobial action of hLF(1-11), we have synthesised several peptides analogues derived from hLF(1- 11) to test their activity against various fungal and bacterial strains. In this way, a general trend on the importance of the order and position of amino acid residues for biological activity against various organisms could be drawn.

 https://crimsonpublishers.com/cjmi/fulltext/CJMI.000512.php

For more open access journals in Crimson Publishers please click on link: https://crimsonpublishers.com/
For more articles in Cohesive Journal of Microbiology & Infectious Disease please click on link: https://crimsonpublishers.com/cjmi/