Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS-Crimson Publishers

Human Monocyte/Macrophage Fungicidal Activity of GM-CSF Against Paracoccidioides brasiliensis Depends on ROS by João Paulo Martins do Carmo in Cohesive Journal of Microbiology & Infectious Disease

The ability of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate human monocytes/macrophages for virulent Paracoccidioides brasiliensis killing was evaluated. Peripheral blood monocytes (MO) and monocyte-derived macrophages (M∅) were activated with different concentrations of GM-CSF. Afterwards, cells were challenged with P. brasiliensis strain 18 (Pb18) and the fungicidal activity was evaluated, plating and counting the Colony Forming Units (CFU) after 10 days. GM-CSF activated MO and M∅ for P. brasiliensis killling in a concentration-dependent manner. There was an association between this fungicidal activity and the high levels of H₂O₂ release by the activated cells

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